COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

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dc.contributor.authorTomlinson, Ian P.
dc.contributor.authorDunlop, Malcolm
dc.contributor.authorCampbell, Harry
dc.contributor.authorZanke, Brent W.
dc.contributor.authorGallinger, Steven
dc.contributor.authorHudson, Thomas J.
dc.contributor.authorKoessler, Thibaud
dc.contributor.authorPharoah, Paul D. P.
dc.contributor.authorNiittymäki, Iina
dc.contributor.authorTuupanen, Sari
dc.contributor.authorAaltonen, Lauri A.
dc.contributor.authorHemminki, Kari
dc.contributor.authorLindblom, Annika
dc.contributor.authorFörsti, Asta
dc.contributor.authorSieber, Oliver
dc.contributor.authorLipton, Lara
dc.contributor.authorVan Wezel, Tom
dc.contributor.authorMorreau, Hans
dc.contributor.authorWijnen, Juul
dc.contributor.authorDevilee, Peter
dc.contributor.authorMatsuda, Kenji
dc.contributor.authorNakamura, Yusuke
dc.contributor.authorCastellví Bel, Sergi
dc.contributor.authorRuiz-Ponte, Clara
dc.contributor.authorCastells Garangou, Antoni
dc.contributor.authorCarracedo Álvarez, Ángel
dc.contributor.authorHo, J.W.
dc.contributor.authorSham, Pak Chung
dc.contributor.authorHofstra, Robert
dc.contributor.authorVodicka, Pavel
dc.contributor.authorBrenner, Hermann
dc.contributor.authorHampe, Jochen
dc.contributor.authorSchafmayer, Clemens
dc.contributor.authorTepel, Juergen
dc.contributor.authorSchreiber, Stefan
dc.contributor.authorVölzke, Henry
dc.contributor.authorLerch, Markus M.
dc.contributor.authorSchmidt, Christian A.
dc.contributor.authorBuch, Stephan
dc.contributor.authorMoreno Aguado, Víctor
dc.date.accessioned2020-01-07T16:03:55Z
dc.date.available2020-01-07T16:03:55Z
dc.date.issued2010-07-15
dc.date.updated2020-01-07T16:03:55Z
dc.description.abstractIt is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec593140
dc.identifier.issn0007-0920
dc.identifier.pmid19920828
dc.identifier.urihttps://hdl.handle.net/2445/147117
dc.language.isoeng
dc.publisherCancer Research UK
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1038/sj.bjc.6605338
dc.relation.ispartofBritish Journal of Cancer, 2010, vol. 102, num. 2, p. 447-454
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/223678/EU//CHIBCHA
dc.relation.urihttps://doi.org/10.1038/sj.bjc.6605338
dc.rights(c) Tomlinson, Ian P. et al., 2010
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Ciències Clíniques)
dc.subject.classificationCàncer colorectal
dc.subject.classificationGenètica
dc.subject.classificationPolimorfisme genètic
dc.subject.otherColorectal cancer
dc.subject.otherGenetics
dc.subject.otherGenetic polymorphisms
dc.titleCOGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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