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CH0002_de+Larrea_v2.pdf (173.83 KB)

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Published version

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2023-08-01

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cc by-nc-nd (c) Elsevier, 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/207222

Clinical Implications of Genomic Profile in Waldenström Macroglobulinemia

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https://doi.org/10.1016/j.hoc.2023.04.002

Abstract

With the increasing availability of sequencing techniques and new polymerase chain reaction-based methods, data regarding the genomic profile of Waldenström macroglobulinemia (WM) are being continuously analyzed and reproduced. MYD88 and CXCR4 mutations are highly prevalent in all the stages of WM, including the early IgM monoclonal gammopathy of undetermined significance or a more advanced stage, such as smoldering WM. Thus, there is a need to define genotypes before starting either standard treatment regimens or clinical trials. Here, we review the genomic profile of WM and its clinical implications while focusing on recent advances.Copyright © 2023 Elsevier Inc. All rights reserved.

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Limfomes, Mutació (Biologia)

Subject (English)

Lymphomas, Mutation (Biology)

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

MORENO FAJARDO, David Fernando and FERNÁNDEZ DE LARREA RODRÍGUEZ, Carlos José. Clinical Implications of Genomic Profile in Waldenström Macroglobulinemia. Hematology-Oncology Clinics Of North America. 2023. Vol. 37, num. 4, pags. 659-670. ISSN 0889-8588. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/207222

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