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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/128327
Relationship Between Biofilm Formation and Antimicrobial Resistance in Gram-Negative Bacteria
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Abstract
Gram-negative microorganisms are a significant cause of
infection in both community and nosocomial settings. The
increase, emergence, and spread of antimicrobial resistance
among bacteria are the most important health problems worldwide.
One of the mechanisms of resistance used by bacteria is biofilm
formation, which is also a mechanism of virulence. This study
analyzed the possible relationship between antimicrobial
resistance and biofilm formation among isolates of three
Gram-negative bacteria species. Several relationships were found
between the ability to form biofilm and antimicrobial
resistance, being different for each species. Indeed, gentamicin
and ceftazidime resistance was related to biofilm formation in
Escherichia coli, piperacillin/tazobactam, and colistin in
Klebsiella pneumoniae, and ciprofloxacin in Pseudomonas
aeruginosa. However, no relationship was observed between global
resistance or multidrug-resistance and biofilm formation. In
addition, compared with other reported data, the isolates in the
present study showed higher rates of antimicrobial resistance.
In conclusion, the acquisition of specific antimicrobial
resistance can compromise or enhance biofilm formation in
several species of Gram-negative bacteria. However,
multidrug-resistant isolates do not show a trend to being
greater biofilm producers than non-multiresistant isolates.
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CEPAS, Virginio, et al. Relationship Between Biofilm Formation and Antimicrobial
Resistance in Gram-Negative Bacteria. Microbial Drug Resistance. 2019. Vol. 25, num. 1. ISSN 1076-6294. [consulted: 7 of October of 2026]. Available at: https://hdl.handle.net/2445/128327