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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222655
CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
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Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
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SANS DE SAN NICOLÀS, Lídia, et al. CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis. Allergy. 2024. Vol. 79, num. 1, pags. 15-25. ISSN 0105-4538. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/222655