CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis

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dc.contributor.authorSans de San Nicolàs, Lídia
dc.contributor.authorCzarnowicki, Tali
dc.contributor.authorAkdis, Mubeccel
dc.contributor.authorPujol, Ramon M.
dc.contributor.authorLozano-Ojalvo, Daniel
dc.contributor.authorLeung, Donald Y. M.
dc.contributor.authorGuttman-Yassky, Emma
dc.contributor.authorSantamaria Babí, Luis F.
dc.date.accessioned2025-07-29T10:08:23Z
dc.date.available2025-07-29T10:08:23Z
dc.date.issued2023-07-13
dc.date.updated2025-07-29T10:08:23Z
dc.description.abstractCirculating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec743209
dc.identifier.issn0105-4538
dc.identifier.urihttps://hdl.handle.net/2445/222655
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1111/all.15816
dc.relation.ispartofAllergy, 2024, vol. 79, num.1, p. 15-25
dc.relation.urihttps://doi.org/10.1111/all.15816
dc.rightscc by-nc 4.0 (c) Sans-de San Nicolàs, L., et al., 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceArticles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
dc.subject.classificationMarcadors bioquímics
dc.subject.classificationDermatitis atòpica
dc.subject.classificationCèl·lules T
dc.subject.otherBiochemical markers
dc.subject.otherAtopic dermatitis
dc.subject.otherT cells
dc.titleCLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)