Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/119571
Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Common single-nucleotide polymorphisms (SNPs) account for a large proportion of the heritability of obsessive-compulsive disorder (OCD). Co-ocurrence of OCD and schizophrenia is commoner than expected based on their respective prevalences, complicating the clinical management of patients. This study addresses two main objectives: to identify particular genes associated with OCD by SNP-based and gene-based tests; and to test the existence of a polygenic risk shared with schizophrenia. The primary analysis was an exon-focused genome-wide association study of 370 OCD cases and 443 controls from Spain. A polygenic risk model based on the Psychiatric Genetics Consortium schizophrenia data set (PGC-SCZ2) was tested in our OCD data. A polygenic risk model based on our OCD data was tested on previous data of schizophrenia from our group. The most significant association at the gene-based test was found at DNM3 (P=7.9 × 10(-5)), a gene involved in synaptic vesicle endocytosis. The polygenic risk model from PGC-SCZ2 data was strongly associated with disease status in our OCD sample, reaching its most significant value after removal of the major histocompatibility complex region (lowest P=2.3 × 10(-6), explaining 3.7% of the variance). The shared polygenic risk was confirmed in our schizophrenia data. In conclusion, DNM3 may be involved in risk to OCD. The shared polygenic risk between schizophrenia and OCD may be partially responsible for the frequent comorbidity of both disorders, explaining epidemiological data on cross-disorder risk. This common etiology may have clinical implications.
Matèries (anglès)
Citació
Citació
COSTAS, Javier, CARRERA, Noa, ALONSO, Pino, GURRIARÁN, X., SEGALÀS COSI, Cinto, REAL, Eva, LÓPEZ SOLÀ, Clara, MAS HERRERO, Sergi, GASSÓ ASTORGA, Patricia, DOMÈNECH, Lluis, MORELL, Marta, QUINTELA, Inés, LÁZARO GARCÍA, Luisa, MENCHÓN MAGRIÑÁ, José manuel, ESTIVILL, Xavier, CARRACEDO, Arkaitz. Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia. _Translational Psychiatry_. 2016. Vol. 6, núm. e768. [consulta: 7 de febrer de 2026]. ISSN: 2158-3188. [Disponible a: https://hdl.handle.net/2445/119571]