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Article

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Published version

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2015-07-07

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cc-by (c) Fredrick R. Schumacher et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/124064

Genome-wide association study of colorectal cancer identifies six new susceptibility loci

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https://doi.org/10.1038/ncomms8138

Abstract

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

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El document inclou una pàgina final amb una correcció (corrigendum). Aquesta, per si sola, té el següent DOI: 10.1038/ncomms9739 i es va publicar al mateix vol. 6.

Subject

Càncer colorectal, Genoma humà, Genètica

Subject (English)

Colorectal cancer, Human genome, Genetics

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

Fredrick R. Schumacher, et al. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nature Communications. 2015. Vol. 6, num. 7138, pags. 1-6. ISSN 2041-1723. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/124064

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