Genome-wide association study of colorectal cancer identifies six new susceptibility loci

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dc.contributor.authorFredrick R. Schumacher
dc.contributor.authorSchmit, Stephanie L.
dc.contributor.authorJiao, Shuo
dc.contributor.authorEdlund, Christopher K.
dc.contributor.authorWang, Hansong
dc.contributor.authorZhang, Ben
dc.contributor.authorHsu, Li
dc.contributor.authorHuang, Shu-Chen
dc.contributor.authorFischer, Christopher P.
dc.contributor.authorHarju, John F.
dc.contributor.authorIdos, Gregory E.
dc.contributor.authorLejbkowicz, Flavio
dc.contributor.authorManion, Frank J.
dc.contributor.authorMcDonnell, Kevin
dc.contributor.authorMcNeil, Caroline E.
dc.contributor.authorMelas, Marilena
dc.contributor.authorRennert, Hedy S.
dc.contributor.authorShi, Wei
dc.contributor.authorThomas, Duncan C.
dc.contributor.authorBerg, David J. Van den
dc.contributor.authorHutter, Carolyn M.
dc.contributor.authorAragaki, Aaron K.
dc.contributor.authorButterbach, Katja
dc.contributor.authorCaan, Bette J.
dc.contributor.authorCarlson, Christopher S.
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorCurtis, Keith R.
dc.contributor.authorFuchs, Charles S.
dc.contributor.authorGala, Manish
dc.contributor.authorGiovannucci, Edward L.
dc.contributor.authorGogarten, Stephanie M.
dc.contributor.authorHayes, Richard B.
dc.contributor.authorHenderson, Brian E.
dc.contributor.authorHunter, David J.
dc.contributor.authorJackson, Rebecca D. J.
dc.contributor.authorKolonel, Laurence N.
dc.contributor.authorKooperberg, Charles
dc.contributor.authorKüry, Sébastien
dc.contributor.authorLaCroix, Andrea
dc.contributor.authorMoreno Aguado, Víctor
dc.date.accessioned2018-08-01T08:58:29Z
dc.date.available2018-08-01T08:58:29Z
dc.date.issued2015-07-07
dc.date.updated2018-08-01T08:58:29Z
dc.descriptionEl document inclou una pàgina final amb una correcció (corrigendum). Aquesta, per si sola, té el següent DOI: 10.1038/ncomms9739 i es va publicar al mateix vol. 6.
dc.description.abstractGenetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec660449
dc.identifier.issn2041-1723
dc.identifier.pmid26151821
dc.identifier.urihttps://hdl.handle.net/2445/124064
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/ncomms8138
dc.relation.ispartofNature Communications, 2015, vol. 6, num. 7138, p. 1-6
dc.relation.urihttps://doi.org/10.1038/ncomms8138
dc.rightscc-by (c) Fredrick R. Schumacher et al., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Ciències Clíniques)
dc.subject.classificationCàncer colorectal
dc.subject.classificationGenoma humà
dc.subject.classificationGenètica
dc.subject.otherColorectal cancer
dc.subject.otherHuman genome
dc.subject.otherGenetics
dc.titleGenome-wide association study of colorectal cancer identifies six new susceptibility loci
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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