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2012-03-12

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cc-by (c) Kurdián et al., 2012
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/34526

Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model

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http://dx.doi.org/10.1371/journal.pone.0032516

Abstract

The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.

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Medicaments, Transplantament renal, Proteïnúria, Immunosupressió

Subject (English)

Drugs, Kidney transplantation, Proteinuria, Immunosuppression

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Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

KURDIÁN, Melania, et al. Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model. PLoS One. 2012. Vol. 7, num. 3, pags. e32516. ISSN 1932-6203. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/34526

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