Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model

Vista senzilla d'ítem
dc.contributor.authorKurdián, Melania
dc.contributor.authorHerrero Fresneda, Immaculada
dc.contributor.authorLloberas Blanch, Núria
dc.contributor.authorGiménez Bonafé, Pepita
dc.contributor.authorCoria, Virginia
dc.contributor.authorGrande, María T.
dc.contributor.authorBoggia, José
dc.contributor.authorMalacrida, Leonel
dc.contributor.authorTorras Ambròs, Joan
dc.contributor.authorArévalo, Miguel A.
dc.contributor.authorGonzález-Martínez, Francisco
dc.contributor.authorLópez-Novoa, José M.
dc.contributor.authorGrinyó Boira, Josep M.
dc.contributor.authorNoboa, Oscar
dc.date.accessioned2013-04-11T11:31:24Z
dc.date.available2013-04-11T11:31:24Z
dc.date.issued2012-03-12
dc.date.updated2013-04-11T11:31:24Z
dc.description.abstractThe immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec606624
dc.identifier.issn1932-6203
dc.identifier.pmid22427849
dc.identifier.urihttps://hdl.handle.net/2445/34526
dc.language.isoengeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032516
dc.relation.ispartofPLoS One, 2012, vol. 7, núm. 3, p. e32516
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0032516
dc.rightscc-by (c) Kurdián et al., 2012
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Ciències Fisiològiques)
dc.subject.classificationMedicamentscat
dc.subject.classificationTransplantament renalcat
dc.subject.classificationProteïnúriacat
dc.subject.classificationImmunosupressiócat
dc.subject.otherDrugseng
dc.subject.otherKidney transplantationeng
dc.subject.otherProteinuriaeng
dc.subject.otherImmunosuppressioneng
dc.titleDelayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction modeleng
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
606624.pdf
Mida:
650.73 KB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))