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2017-08-31

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/115786

Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases

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http://dx.doi.org/10.1002/ijc.31006

Resum

There are at least two different etio-pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent of HPV. We aimed to describe the histological characteristics of HPV-associated and HPV-independent tumors and to determine the best strategy to identify HPV in VSCC. A single paraffin block was available for review from a series of 1594 VSCCs. In all cases HPV DNA detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and p16 immunohistochemistry (IHC). A tumor was considered as unquestionably HPV-associated if both HPV DNA and p16 IHC were positive. A tumor was considered indisputably HPV-independent if both HPV DNA and p16 IHC were negative. Two groups of tumors were classified as non-conclusive: 1) HPV DNA+/p16-; and 2) HPV DNA-/p16+. WHO typing and a thorough histological evaluation were conducted in all cases. 441 tumors were HPV DNA+ with 367 cases (23.0%) being HPV DNA+/p16+. These HPV DNA+/p16+ tumors were more frequently basaloid or warty (49.8%), but 36.5% were of the keratinizing type. 1153 tumors were HPV DNA-, with 1060 cases (66.5%) being HPV DNA-/p16-. These HPV DNA-/p16- tumors were mostly keratinizing (81.2%) but were occasionally basaloid or warty (5.2%). The features of HPV DNA-/p16+ cases (n=93) were similar to those of the HPV-associated VSCC, and HPV DNA+/p16- (n=74) cases had a more diverse profile, although they were more similar to HPV-independent tumors. Several histological characteristics were more frequently associated with HPV-related VSCC (koilocytotic-like change, necrosis, moderate to marked pleomorphism, invasive front in nests; p<0.001), however, none of these characteristics allowed differentiation between HPV-associated and -independent VSCC. In conclusion, histological criteria do not allow differentiation between HPV-associated and -independent VSCC. p16 alone is a clinically easy strategy to determine HPV status in VSCC. This article is protected by copyright. All rights reserved.

Matèries

Papil·lomavirus, Malalties de la vulva

Matèries (anglès)

Papillomaviruses, Vulva diseases

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Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

RAKISLOVA, Natalia, CLAVERO, Omar, ALEMANY I VILCHES, Laia, SACO, Adela, QUIRÓS, Beatriz, LLOVERAS RUBIO, Betlem, ALEJO, Maria, PAWLITA, Michael, QUINT, Wim, PINO SALADRIGUES, Marta del, SANJOSÉ LLONGUERAS, Silvia de, ORDI I MAJÀ, Jaume. Histological characteristics of HPV-associated and -independent squamous cell carcinomas of the vulva: A study of 1594 cases. _International Journal of Cancer_. 2017. pàgs. Ahead of
                print. [consulta: 24 de gener de 2026]. ISSN: 0020-7136. [Disponible a: https://hdl.handle.net/2445/115786]

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