Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

885502.pdf (1.96 MB)

Document type

Article

Version

Published version

Publication date

2024-11-23

Publication license

cc-by-nc-nd (c) López-Hernández, Y. et al., 2024
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/219427

Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: A systematic review

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/https://doi.org/10.1016/j.tranon.2024.102196

Abstract

Prostate cancer (PCa) is one of the leading causes of cancer-related deaths among men. The heterogeneous nature of this disease presents challenges in its diagnosis, prognosis, and treatment. Numerous potential predictive, diagnostic, prognostic, and risk assessment biomarkers have been proposed through various population studies. However, to date, no metabolite biomarker has been approved or validated for the diagnosis, prognosis, or risk assessment of PCa. Recognizing that systematic reviews of case reports or heterogenous studies cannot reliably establish causality, this review analyzed 29 large prospective metabolomics studies that utilized harmonized criteria for patient selection, consistent methodologies for blood sample collection and storage, data analysis, and that are available in public repositories. By focusing on these large prospective studies, we identified 42 metabolites that were consistently replicated by different authors and across cohort studies. These metabolites have the potential to serve as PCa risk-assessment or predictive biomarkers. A discussion on their associations with dietary sources or dietary patterns is also provided. Further detailed exploration of the relationship with diet, supplement intake, nutrition patterns, contaminants, lifestyle factors, and pre-existing comorbidities that may predispose individuals to PCa is warranted for future research and validation.

Subject

Càncer de pròstata, Marcadors bioquímics, Metabòlits

Subject (English)

Prostate cancer, Biochemical markers, Metabolites

Citation

Collections

Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

ANDRÉS LACUEVA, Ma. Cristina, et al. Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: A systematic review. Translational Oncology. 2024. Vol. 51. ISSN 1944-7124. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/219427

Export metadata

JSON - METS

Share record