Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/219427
Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: A systematic review
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Prostate cancer (PCa) is one of the leading causes of cancer-related deaths among men. The heterogeneous nature of this disease presents challenges in its diagnosis, prognosis, and treatment. Numerous potential predictive, diagnostic, prognostic, and risk assessment biomarkers have been proposed through various population studies. However, to date, no metabolite biomarker has been approved or validated for the diagnosis, prognosis, or risk assessment of PCa. Recognizing that systematic reviews of case reports or heterogenous studies cannot reliably establish causality, this review analyzed 29 large prospective metabolomics studies that utilized harmonized criteria for patient selection, consistent methodologies for blood sample collection and storage, data analysis, and that are available in public repositories. By focusing on these large prospective studies, we identified 42 metabolites that were consistently replicated by different authors and across cohort studies. These metabolites have the potential to serve as PCa risk-assessment or predictive biomarkers. A discussion on their associations with dietary sources or dietary patterns is also provided. Further detailed exploration of the relationship with diet, supplement intake, nutrition patterns, contaminants, lifestyle factors, and pre-existing comorbidities that may predispose individuals to PCa is warranted for future research and validation.
Matèries
Matèries (anglès)
Citació
Citació
ANDRÉS LACUEVA, Ma. cristina, LÓPEZ-HERNÁNDEZ, Yamilé, WISHART, David s., TORRES-CALZADA, Claudia, MARTÍNEZ HUÉLAMO, Miriam, ALMANZA AGUILERA, Enrique, ZAMORA-ROS, Raul. Prostate cancer risk biomarkers from large cohort and prospective metabolomics studies: A systematic review. _Translational Oncology_. 2024. Vol. 51. [consulta: 24 de gener de 2026]. ISSN: 1944-7124. [Disponible a: https://hdl.handle.net/2445/219427]