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Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

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dc.contributor.authorFicarra, Guido
dc.contributor.authorPrat Aparicio, Aleix
dc.contributor.authorConte, Pierfranco
dc.contributor.authorGuarneri, Valentina
dc.contributor.authorGriguolo, Gaia
dc.contributor.authorDieci, Maria Vittoria
dc.contributor.authorParé, Laia
dc.contributor.authorMiglietta, Federica
dc.contributor.authorGenerali, Daniele
dc.contributor.authorFrassoldati, Antonio
dc.contributor.authorCavanna, Luigi
dc.contributor.authorBisagni, Giancarlo
dc.contributor.authorPiacentini, Federico
dc.contributor.authorTagliafico, Enrico
dc.contributor.authorCagossi, Katia
dc.date.accessioned2026-01-26T12:45:00Z
dc.date.available2026-01-26T12:45:00Z
dc.date.issued2021-02-12
dc.date.updated2026-01-26T12:45:01Z
dc.description.abstractLittle is known regarding the interaction between immune microenvironment and tumorbiology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatmentgene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocytelevels than luminal tumors. Moreover, significant differences in immune infiltrate composition,assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatoryantitumor immune infiltrate composition than luminal ones.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec759898
dc.identifier.issn2374-4677
dc.identifier.pmid33579951
dc.identifier.urihttps://hdl.handle.net/2445/226145
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41523-021-00223-x
dc.relation.ispartofnpj Breast Cancer, 2021, vol. 7, num.1
dc.relation.urihttps://doi.org/10.1038/s41523-021-00223-x
dc.rightscc-by (c) Griguolo, Gaia et al., 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceArticles publicats en revistes (Medicina)
dc.subject.classificationCàncer de mama
dc.subject.classificationReceptors d'hormones
dc.subject.classificationAntígens tumorals
dc.subject.otherBreast cancer
dc.subject.otherHormone receptors
dc.subject.otherTumor antigens
dc.titleImmune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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