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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/226145
Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
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Little is known regarding the interaction between immune microenvironment and tumorbiology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatmentgene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocytelevels than luminal tumors. Moreover, significant differences in immune infiltrate composition,assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatoryantitumor immune infiltrate composition than luminal ones.
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FICARRA, Guido, et al. Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer. npj Breast Cancer. 2021. Vol. 7, num. 1. ISSN 2374-4677. [consulted: 6 of June of 2026]. Available at: https://hdl.handle.net/2445/226145