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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/190185
Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
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Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-alpha and a decreased expression of TGF-beta and CD206. Regarding cytokine release, there was an increase in IL-1 beta, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers.
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TOLEDANO SERRABONA, Jorge, BOSCH, Begoña m., DÍEZ TERCERO, Leire, GIL, F. x. (francesc xavier), CAMPS FONT, Octavi, VALMASEDA CASTELLÓN, Eduardo, GAY ESCODA, Cosme, SÁNCHEZ GARCÉS, Ma. ángeles. Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants. _Scientific Reports_. 2022. Vol. 12, núm. 1. [consulta: 30 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/190185]