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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225021
Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
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Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.
Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.
Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.
Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.
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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
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MATÍA-MARTÍN, Pilar, SHYAM, Sangeetha, GARCÍA GAVILÁN, Jesús, PAZ-GRANIEL, Indira, GAFORIO, José j., MARTÍNEZ-GONZÁLEZ, Miguel ángel, CORELLA PIQUER, Dolores, MARTÍNEZ HERNÁNDEZ, José alfredo, ALONSO GÓMEZ, Ángel m., WÄRNBERG, Julia, VIOQUE, Jesús, ROMAGUERA, Dora, LÓPEZ-MIRANDA, José, ESTRUCH RIBA, Ramon, TINAHONES, Francisco josé, LAPETRA, José, SERRA-MAJEM, J. luis, BUENO-CAVANILLAS, Aurora, TUR, Josep antoni, MARTÍN-SÁNCHEZ, V., PINTÓ SALA, Xavier, VIDAL I CORTADA, Josep, VÁZQUEZ, Clotilde, DAIMIEL, Lidia, ROS RAHOLA, Emilio, FERNÁNDEZ ARANDA, Fernando, NISHI, Stephanie k, GARCIA-REGATA, Oscar, TOLEDO, Estefanía, ASENSIO, Eva m, CASTAÑER NIÑO, Olga, GARCIA-RIOS, Antonio, TORRES-COLLADO, Laura, GÓMEZ GRACIA, Enrique, ZULET, M. angeles, GOÑI RUIZ, Nuria, CASAS RODRÍGUEZ, Rosa m., CANO IBÁÑEZ, Naomi, TOJAL-SIERRA, Lucas, GÓMEZ-PEREZ, Am, SORLÍ, José v, CINZA-SANJURJO, Sergio, MARTÍN-PELÁEZ, Sandra, PEÑA-ORIHUELA, Patricia j, ONCINA-CANOVAS, Alejandro, PEREZ-ARALUCE, Rafael, ZOMEÑO, Maria dolores, CHAPLIN, Alice, DELGADO RODRIGUEZ, Miguel, BABIO, Nancy, FITÓ COLOMER, Montserrat, SALAS-SALVADÓ, Jordi. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort. _BMC Medicine_. 2023. Vol. 21, núm. 1. [consulta: 5 de gener de 2026]. ISSN: 1741-7015. [Disponible a: https://hdl.handle.net/2445/225021]