Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

605680.pdf (1.79 MB)

Document type

Article

Version

Published version

Publication date

2011

Publication license

cc-by (c) Martínez et al., 2011
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/62905

Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

http://dx.doi.org/10.1371/journal.pone.0027999

Abstract

The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties.

Subject

Biofísica, Síntesi de pèptids, Malalties neurodegeneratives, Aminoàcids, Citotoxicitat per mediació cel·lular, Polímers, Oxidació

Subject (English)

Biophysics, Peptide synthesis, Neurodegenerative Diseases, Amino acids, Cell-mediated cytotoxicity, Polymers, Oxidation

Citation

Collections

Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

MARTÍNEZ GONZÁLEZ, Javier, et al. Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity. PLoS One. 2011. Vol. 6, num. 11, pags. e27999. ISSN 1932-6203. [consulted: 13 of August of 2026]. Available at: https://hdl.handle.net/2445/62905

Export metadata

JSON - METS

Share record