Selenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.

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dc.contributor.authorMartínez González, Javier
dc.contributor.authorLisa, Silvia
dc.contributor.authorSánchez, Rosa
dc.contributor.authorKowalczyk, Wioleta
dc.contributor.authorZurita, Esther
dc.contributor.authorTeixidó Turà, Meritxell
dc.contributor.authorGiralt Lledó, Ernest
dc.contributor.authorAndreu Martínez, David
dc.contributor.authorAvila, Jesús
dc.contributor.authorGasset, María
dc.date.accessioned2015-02-13T11:31:41Z
dc.date.available2015-02-13T11:31:41Z
dc.date.issued2011
dc.date.updated2015-02-13T11:31:41Z
dc.description.abstractThe capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical methionine (Met) residues which in vivo can be synthetically substituted by selenomethionine (SeM) and alter their properties.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec605680
dc.identifier.issn1932-6203
dc.identifier.pmid22132190
dc.identifier.urihttps://hdl.handle.net/2445/62905
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0027999
dc.relation.ispartofPLoS One, 2011, vol. 6, num. 11, p. e27999
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0027999
dc.rightscc-by (c) Martínez et al., 2011
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationBiofísica
dc.subject.classificationSíntesi de pèptids
dc.subject.classificationMalalties neurodegeneratives
dc.subject.classificationAminoàcids
dc.subject.classificationCitotoxicitat per mediació cel·lular
dc.subject.classificationPolímers
dc.subject.classificationOxidació
dc.subject.otherBiophysics
dc.subject.otherPeptide synthesis
dc.subject.otherNeurodegenerative Diseases
dc.subject.otherAmino acids
dc.subject.otherCell-mediated cytotoxicity
dc.subject.otherPolymers
dc.subject.otherOxidation
dc.titleSelenomethionine incorporation into amyloid sequences regulates fibrillogenesis and toxicity.
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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