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A prospective, randomized, triple-blind comparison of articaine and bupivacaine for maxillary infiltrations
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Objectives: To compare the clinical anesthetic efficacy of 0.5% bupivacaine and 4% articaine (both with 1:200.000 adrenaline) for anterior maxillary infiltration in healthy volunteers. Material and methods: A triple-blind split-mouth randomized clinical trial was carried out in 20 volunteers. A supraperiosteal buccal injection of 0.9 ml of either solution at the apex of the lateral incisor was done in 2 appointments separated 2 weeks apart. The following outcome variables were measured: latency time, anesthetic efficacy (dental pulp, keratinized gingiva, alveolar mucosa and upper lip mucosa and tissue) and the duration of anesthetic effect. Hemodynamic parameters were monitored during the procedure. Results: Latency time recorded was similar for both anesthetic solutions (p>0.05). No statistically significant differences were found in terms of anesthetic efficacy for dental pulp, keratinized gingiva or alveolar mucosa. Articaine had a significant higher proportion of successful anesthesia at 10 minutes after infiltration in lip mucosa and lip skin (p=0.039). The duration of anesthesia was 336 minutes for bupivacaine and 167 minutes for articaine. (p<0.001). No significant hemodynamic alterations were noted during the procedure. Conclusions: Articaine and bupivacaine exhibited similar anesthetic efficacy for maxillary infiltrations. The duration of anesthesia was longer with the bupivacaine solution, but lip anesthesia was better with articaine
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VÍLCHEZ PÉREZ, Miguel-ángel, SANCHO PUCHADES, Manuel, VALMASEDA CASTELLÓN, Eduardo, PAREDES GARCÍA, Jordi, BERINI AYTÉS, Leonardo, GAY ESCODA, Cosme. A prospective, randomized, triple-blind comparison of articaine and bupivacaine for maxillary infiltrations. _Medicina Oral_. Patología Oral y Cirugia Bucal. Vol. 2012, núm. 17, pàgs. 2. [consulta: 23 de gener de 2026]. ISSN: 1698-4447. [Disponible a: https://hdl.handle.net/2445/48337]