Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227925
The multiomics blueprint of the individual with the most extreme lifespan
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
Matèries
Matèries (anglès)
Citació
Citació
TORRUBIANO, Marta, MASSIP SALCEDO, Marta, KHIDIR, Kamal a., CAO, Thong huy, QUINN, Paulene a., JONES, Donald j. l., MACIP, Salvador, BRIGOS BARRIL, Eva, MOLDES, Mauricio, BARTERI, Fabio, FERRER, Gerardo, MUNTANÉ, Gerard, DAVALOS, Veronica, LAAYOUNI, Hafid, MEREU, Elisabetta, NAVARRO, Arcadi, PLUVINET, Raquel, ESTELLER, Manel, ARRIBAS, Carles, TORRE, Carolina de la, VILLAVICENCIO GOULA, Francisco, SUMOY, Lauro, GRANADA, Isabel, COLES, Natalie s., SANTOS PUJOL, Eloy, NOGUERA CASTELLS, Aleix, CASADO PELAEZ, Marta, GARCÍA PRIETO, Carlos a., VASALLO, Claudia, CAMPILLO MARCOS, Ignacio, QUERO DOTOR, Carlos, CRESPO GARCÍA, Eva, BUENO COSTA, Alberto, SETIÉN, Fernando, ACHA, Pamela, SOLÉ, Francesc, MALLO, Mar, MATA, Caterina, PEREGRINA, Sara, GABALDÓN, Toni, LLIRÓS, Marc, PUJOLASSOS, Meritxell, CARRERA TORRES, Robert, LLUANSÍ, Aleix, GARCÍA GIL, Librado jesús, ALDEGUER, Xavier, SAMINO, Sara, TORNÉ, Pol, RIBALTA, Josep, GUARDIOLA, Montse, AMIGÓ, Núria, YANES, Oscar, MARTÍNEZ, Paula, SÁNCHEZ VÁZQUEZ, Raúl, BLASCO, Maria a., OVIEDO, Jose, LEMOS, Bernardo, RIUS BONET, Julia. The multiomics blueprint of the individual with the most extreme lifespan. _Cell Reports Medicine_. 2025. Vol. 6, núm. 10. [consulta: 25 de març de 2026]. ISSN: 2666-3791. [Disponible a: https://hdl.handle.net/2445/227925]