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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185901
Generation of an induced pluripotent stem cell line from a healthy Caucasian male
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The effects of genetic mutations on protein function can be studied in a physiologically relevant environment using tissue-specific cells differentiated from patient-derived induced pluripotent stem cells (iPSC). However, it is crucial to use iPSC derived from healthy individuals as control. We generated an iPS cell line from skin fibroblasts of a healthy Caucasian male by nucleofection of non-integrating episomal vectors. This cell line has normal karyotype, expresses pluripotency surface markers and pluripotency genes, and successfully differentiates into cells of the 3 germ layers. Therefore, it can be used as control for any disease of interest that is modelled using iPSC.
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MARTÍNEZ MORENO, Rebecca, PÉREZ SERRA, Alexandra, CARRERAS, David, ARAN CORBELLA, Begoña, KUEBLER, Bernd, BRUGADA, Ramon, SCORNIK, Fabiana s., PÉREZ, Guillermo j., SELGA I COMA, Elisabet. Generation of an induced pluripotent stem cell line from a healthy Caucasian male. _Stem Cell Research_. 2022. Vol. 60. [consulta: 20 de gener de 2026]. ISSN: 1873-5061. [Disponible a: https://hdl.handle.net/2445/185901]