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Generation of an induced pluripotent stem cell line from a healthy Caucasian male

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dc.contributor.authorMartínez Moreno, Rebecca
dc.contributor.authorPérez Serra, Alexandra
dc.contributor.authorCarreras, David
dc.contributor.authorAran Corbella, Begoña
dc.contributor.authorKuebler, Bernd
dc.contributor.authorBrugada, Ramon
dc.contributor.authorScornik, Fabiana S.
dc.contributor.authorPérez, Guillermo J.
dc.contributor.authorSelga i Coma, Elisabet
dc.date.accessioned2022-05-23T08:32:08Z
dc.date.available2022-05-23T08:32:08Z
dc.date.issued2022-02-01
dc.date.updated2022-05-19T08:08:41Z
dc.description.abstractThe effects of genetic mutations on protein function can be studied in a physiologically relevant environment using tissue-specific cells differentiated from patient-derived induced pluripotent stem cells (iPSC). However, it is crucial to use iPSC derived from healthy individuals as control. We generated an iPS cell line from skin fibroblasts of a healthy Caucasian male by nucleofection of non-integrating episomal vectors. This cell line has normal karyotype, expresses pluripotency surface markers and pluripotency genes, and successfully differentiates into cells of the 3 germ layers. Therefore, it can be used as control for any disease of interest that is modelled using iPSC.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn1873-5061
dc.identifier.pmid35231795
dc.identifier.urihttps://hdl.handle.net/2445/185901
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.scr.2022.102717
dc.relation.ispartofStem Cell Research, 2022, vol. 60
dc.relation.urihttps://doi.org/10.1016/j.scr.2022.102717
dc.rightscc by-nc-nd (c) Martínez Moreno, Rebecca et al, 2022
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationFibroblasts
dc.subject.classificationSistemes de control biològic
dc.subject.otherFibroblasts
dc.subject.otherBiological control systems
dc.titleGeneration of an induced pluripotent stem cell line from a healthy Caucasian male
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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