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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/121739
Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development
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Objective. To evaluate the long-Term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®. Results. At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β (P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group. Conclusions. Long-Term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.
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CASAS RODRÍGUEZ, Rosa m., URPÍ SARDÀ, Mireia, SACANELLA MESEGUER, Emilio, ARRANZ MARTÍNEZ, Sara, CORELLA PIQUER, Dolores, CASTAÑER, Olga, LAMUELA RAVENTÓS, Rosa ma., SALAS SALVADÓ, Jordi, LAPETRA, José, PORTILLO, María puy, ESTRUCH RIBA, Ramon. Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development. _Mediators of Inflammation_. 2017. Vol. 2017, núm. 3674390. [consulta: 24 de gener de 2026]. ISSN: 0962-9351. [Disponible a: https://hdl.handle.net/2445/121739]