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2025-08-29

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cc-by-nc (c) Alemán-Fernández E et al., 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/224776

Explicit criteria for Potentially Inappropriate Medications in Older Adults: A comprehensive systematic review.

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https://doi.org/10.56499/jppres25.2487_13.6.1797

Abstract

Context: Potentially inappropriate medications (PIMs) refer to the use of a medication whose risks outweigh the potential benefits in older adults, especially when other effective alternatives are available.

Aims: To identify and analyze explicit criteria developed for detecting PIMs in older adults, highlighting methodological approaches and pharmacological classifications.

Methods: A comprehensive literature search was conducted across seven databases from January 1990 to December 2024, following the PRISMA 2020 guidelines. Criteria developed using expert consensus or evidence-based processes were included.

Results: Out of 3,119 articles, 68 met the inclusion criteria. The Beers and STOPP/START tools were most frequently cited. The Delphi method was the predominant approach for validating the selected tools (73.53%). Commonly flagged medications included tricyclic antidepressants, NSAIDs, and benzodiazepines.

Conclusions: Numerous validated tools exist, although variations in validation methods and drug classification were observed. A global update and harmonization of explicit criteria are necessary for improved geriatric pharmacotherapy.

Keywords: Beers criteria; Delphi method; deprescribing tools; older adults; potentially inappropriate medications; STOPP START criteria.

Subject

Persones grans, Medicaments, Envelliment

Subject (English)

Older people, Drugs, Aging

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Citation

ALEMÁN FERNÁNDEZ, Eliezer, et al. Explicit criteria for Potentially Inappropriate Medications in Older Adults: A comprehensive systematic review. Journal of Pharmacy & Pharmacognosy Research. 2025. Vol. 13, num. 6, pags. 1797-1818. ISSN 0719-4250. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/224776

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