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2003-08

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/54973

The role of Serratia marcescens porins in antibiotic resistance

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Recurs relacionat

http://dx.doi.org/10.1089/107662903322286463

Resum

The outer membrane permeability of Serratia marcescens was studied by comparing porin-deficient mutants with their parental strains. Omp1-deficient strains were selected by moxalactam resistance, whereas mutants lacking the Omp2 porin were obtained by experimental infection with the SMP2 phage, whose primary receptor is the Omp2 porin. The role of porins was demonstrated in quinolone accumulation assays, where semi-quantitative differences in accumulation were observed. Permeability coefficients to cephaloridine of Omp1 mutants were determined and compared with those of the parental strain. The clinical isolates S. marcescens HCPR1 and 866 showed 30- to 200-fold reduced permeability coefficients when Omp1 porin was absent

Matèries

Resistència als medicaments, Antibiòtics, Medicaments antibacterians, Serratia marcescens

Matèries (anglès)

Drug resistance, Antibiotics, Antibacterial agents, Serratia marcescens

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Col·leccions

Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Patologia i Terapèutica Experimental)

Citació

RUIZ ESPAÑA, Neus, et al. The role of Serratia marcescens porins in antibiotic resistance. Microbial Drug Resistance. 2003. Vol. 9, num. 3, pags. 257-264. ISSN 1076-6294. [consulted: 12 of July of 2026]. Available at: https://hdl.handle.net/2445/54973

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