The role of Serratia marcescens porins in antibiotic resistance

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dc.contributor.authorRuiz España, Neus
dc.contributor.authorMontero Barrientos, Ma. Teresa
dc.contributor.authorBorrell Hernández, Jordi
dc.contributor.authorViñas, Miquel
dc.date.accessioned2014-06-13T09:34:14Z
dc.date.available2014-06-13T09:34:14Z
dc.date.issued2003-08
dc.date.updated2014-06-13T09:34:14Z
dc.description.abstractThe outer membrane permeability of Serratia marcescens was studied by comparing porin-deficient mutants with their parental strains. Omp1-deficient strains were selected by moxalactam resistance, whereas mutants lacking the Omp2 porin were obtained by experimental infection with the SMP2 phage, whose primary receptor is the Omp2 porin. The role of porins was demonstrated in quinolone accumulation assays, where semi-quantitative differences in accumulation were observed. Permeability coefficients to cephaloridine of Omp1 mutants were determined and compared with those of the parental strain. The clinical isolates S. marcescens HCPR1 and 866 showed 30- to 200-fold reduced permeability coefficients when Omp1 porin was absent
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec510659
dc.identifier.issn1076-6294
dc.identifier.urihttps://hdl.handle.net/2445/54973
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1089/107662903322286463
dc.relation.ispartofMicrobial Drug Resistance, 2003, vol. 9, num. 3, p. 257-264
dc.relation.urihttp://dx.doi.org/10.1089/107662903322286463
dc.rights(c) Mary Ann Liebert, Inc., 2003
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
dc.subject.classificationResistència als medicaments
dc.subject.classificationAntibiòtics
dc.subject.classificationMedicaments antibacterianscat
dc.subject.classificationSerratia marcescenscat
dc.subject.otherDrug resistance
dc.subject.otherAntibiotics
dc.subject.otherAntibacterial agentseng
dc.subject.otherSerratia marcescenseng
dc.titleThe role of Serratia marcescens porins in antibiotic resistanceeng
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
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