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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/204083
Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
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Currently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p=0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (Xpert®MTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation.
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CAMPRUBÍ, Daniel, GOMILA GRANGE, Aina, GRIJOTA CAMINO, Mª de los desamparados, SOLDEVILA-BOIXADER, Laura, LUQUE, Maria j., ALCAIDE FERNÁNDEZ DE VEGA, Fernando, DORCA I SARGATAL, Jordi, SANTÍN CEREZALES, Miguel. Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF. _Journal of Infection_. 2020. Vol. 80, núm. 3, pàgs. 298-300. [consulta: 25 de febrer de 2026]. ISSN: 0163-4453. [Disponible a: https://hdl.handle.net/2445/204083]