Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF

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dc.contributor.authorCamprubí, Daniel
dc.contributor.authorGomila Grange, Aina
dc.contributor.authorGrijota Camino, Mª de los Desamparados
dc.contributor.authorSoldevila-Boixader, Laura
dc.contributor.authorLuque, Maria J.
dc.contributor.authorAlcaide Fernández de Vega, Fernando
dc.contributor.authorDorca i Sargatal, Jordi
dc.contributor.authorSantín Cerezales, Miguel
dc.date.accessioned2023-12-01T17:29:04Z
dc.date.available2023-12-01T17:29:04Z
dc.date.issued2020-03
dc.date.updated2023-12-01T17:29:04Z
dc.description.abstractCurrently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p=0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (Xpert®MTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation.
dc.format.extent3 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec695786
dc.identifier.issn0163-4453
dc.identifier.pmid31954744
dc.identifier.urihttps://hdl.handle.net/2445/204083
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.jinf.2019.12.023
dc.relation.ispartofJournal of Infection, 2020, vol. 80, num.3, p. 298-300
dc.relation.urihttps://doi.org/10.1016/j.jinf.2019.12.023
dc.rightscc-by-nc-nd (c) The British Infection Association, 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceArticles publicats en revistes (Ciències Clíniques)
dc.subject.classificationTuberculosi
dc.subject.classificationReacció en cadena de la polimerasa
dc.subject.otherTuberculosis
dc.subject.otherPolymerase chain reaction
dc.titleInfectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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