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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/199471
Development of a microphysiological system with integrated electrodes for cardiac cell culture, stimulation and sensing
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Abstract
This project focuses on the development and experimentation of a microfluidic device with
integrated electrodes, specifically designed to support the growth and maturation of a 3D cardiac
cell matrix. The goal is to create a functional system that not only enables the cells to thrive and
pump, but also facilitates the propagation of electrical stimuli, mimicking the behavior of natural
cardiovascular tissue.
The motivation behind this research stems from the limited regenerative capacity of adult heart
tissue, particularly when it comes to cardiomyocytes. Traditional healing methods are often
inadequate, necessitating heart transplants as the only definitive treatment option. To address this
challenge, scientists are exploring the potential of biomaterial scaffolds to regenerate
cardiovascular tissue by replacing damaged or necrotic tissue.
The microfluidic device developed in this project holds great promise for researchers in the
pharmaceutical field, offering a valuable tool for drug testing and disease modeling. Despite facing
challenges in incorporating gold electrodes into the device, the team has successfully characterized
it using an EIS machine. The design of the microelectrodes and microchannels, along with the
overall functionality of the microchip, have been accomplished. While the current focus has been
on a 2D layer of cells, the future objectives involve achieving a fully functional 3D matrix to fulfill
the original research goals.
Overall, this project aims to represent a significant step towards the advancement of regenerative
medicine and the potential for innovative solutions in treating cardiovascular diseases.
Description
Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2022-2023. Tutor/Director: Rodríguez Trujillo, Romen
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LLOVERAS BORRÀS, Berta. Development of a microphysiological system with integrated electrodes for cardiac cell culture, stimulation and sensing. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/199471