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2017-05-20

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/174864

Efficacy and safety of direct-acting antiviral agents when combined with secukinumab

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Recurs relacionat

https://doi.org/10.1136/ejhpharm-2017-001212

Resum

Background: The interference in the immune response induced by biological disease-modifying antirheumatic drugs (bDMARDs) increases the risk of reactivation of infections. Treatment of patients with chronic hepatitis C virus (HCV) infection and psoriasis is complex. The efficacy and safety of the new direct-acting antiviral agents (DAA) when combined with bDMARDs remain unknown. Case report: We present a case of a 44-year-old Caucasian man affected with psoriasis and HCV infection. Throughout the course of the psoriatic disease, this patient received several lines of treatment, including secukinumab, a new type of bDMARD. At the time of commencing secukinumab, new DAA agents (ledipasvir/sofosbuvir) were also initiated. At week 12 post-treatment, hepatitis C viral load was undetectable and the patient remained in remission of psoriasis. Conclusion: This case report suggests that secukinumab is a therapeutic option in patients with psoriasis, particularly in those cases with HCV infection where treatment with DAA agents is warranted.

Matèries

Hepatitis C, Malalties autoimmunitàries, Interaccions dels medicaments

Matèries (anglès)

Hepatitis C, Autoimmune diseases, Drug interactions

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Articles publicats en revistes (Medicina)

Citació

MARTÍNEZ SANTANA, Virginia, et al. Efficacy and safety of direct-acting antiviral agents when combined with secukinumab. European Journal Of Hospital Pharmacy-Science And Practice. 2018. Vol. 25, num. 1, pags. 53-56. ISSN 2047-9956. [consulted: 4 of August of 2026]. Available at: https://hdl.handle.net/2445/174864

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