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Publication date

2017-03-18

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cc-by (c) Meli, Alessandra et al., 2017
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/157647

Phakillestatins: an underwater unsolved puzzle

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https://doi.org/10.3390/md15030078

Abstract

A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1-19), cytotoxic proline‐rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various‐sized natural macrocycles are described, along with the total syntheses and the enigmatic issues of the cytotoxic activity reproducibility.

Subject

Aminoàcids, Síntesi de pèptids, Farmacologia

Subject (English)

Amino acids, Peptide synthesis, Pharmacology

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Articles publicats en revistes (Química Inorgànica i Orgànica)
Publicacions de projectes de recerca finançats per la UE

Citation

MELI, Alessandra, et al. Phakillestatins: an underwater unsolved puzzle. Marine Drugs. 2017. Vol. 15, num. 3, pags. 78. ISSN 1660-3397. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/157647

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