Optimization of Xanthatin Extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties

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dc.contributor.authorRomero, M.
dc.contributor.authorZanuy, M.
dc.contributor.authorRosell, E.
dc.contributor.authorCascante i Serratosa, Marta
dc.contributor.authorPiulats, Josep M.
dc.contributor.authorFont Bardia, Ma. Mercedes
dc.contributor.authorBalzirini, J.
dc.contributor.authorde Clercq, E.
dc.contributor.authorPujol Dilmé, M. Dolors
dc.date.accessioned2020-06-06T08:48:27Z
dc.date.available2020-06-06T08:48:27Z
dc.date.issued2015-01-27
dc.date.updated2020-06-06T08:48:27Z
dc.description.abstractThe aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.
dc.format.extent26 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec648456
dc.identifier.issn0223-5234
dc.identifier.pmid25481815
dc.identifier.urihttps://hdl.handle.net/2445/164558
dc.language.isoeng
dc.publisherElsevier Masson SAS
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.ejmech.2014.11.060
dc.relation.ispartofEuropean Journal of Medicinal Chemistry, 2015, vol. 90, p. 491-496
dc.relation.urihttps://doi.org/10.1016/j.ejmech.2014.11.060
dc.rights(c) Elsevier Masson SAS, 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)
dc.subject.classificationPlantes medicinals
dc.subject.classificationMedicaments antivírics
dc.subject.classificationRadiocristal·lografia
dc.subject.otherMedicinal plants
dc.subject.otherAntiviral agents
dc.subject.otherX-ray crystallography
dc.titleOptimization of Xanthatin Extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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