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Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health<br />
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Scope: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to
assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older
population at high cardiovascular risk.
Methods and results: A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid
chromatography coupled to mass spectrometry is used to identify urinaryMPM.Mediterranean diet (MedDiet) adherence
is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests.
Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet
and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the
MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol
glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests.
Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental
State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.
Conclusions: These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in
an older population.
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CASAS RODRÍGUEZ, Rosa m., DOMÍNGUEZ LÓPEZ, Inés, GALKINA, Polina, PARILLI MOSER, Isabella, ARANCIBIA RIVEROS, Camila, MARTÍNEZ-GONZÁLEZ, Miguel ángel, SALAS SALVADÓ, Jordi, CORELLA PIQUER, Dolores, MALCAMPO, Mireia, MARTÍNEZ HERNÁNDEZ, José alfredo, TOJAL SIERRA, Lucas, WÄRNBERG, Julia, VIOQUE, Jesús, ROMAGUERA, Dora, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, TINAHONES, Francisco j., SANTOS LOZANO, José manuel, SERRA MAJEM, Lluís, BUENO-CAVANILLAS, Aurora, TUR, Josep antoni, RUBÍN GARCÍA, María, PINTÓ SALA, Xavier, Fernández-Aranda F, DELGADO RODRIGUEZ, Miguel, BARABASH, Ana, VIDAL, Josep, VÁZQUEZ, Clotilde, DAIMIEL, Lidia, ROS RAHOLA, Emilio, TOLEDO ATUCHA, Estefanía, ATZENI, Alessandro, ASENSIO, Eva m., VERA, Natàlia, GARCÍA-RÍOS, Antonio, TORRES COLLADO, Laura, PÉREZ-FARINÓS, Napoleón, ZULET, M. angeles, CHAPLIN, Alice, MARTÍN-PELÁEZ, Sandra, VAQUERO LUNA, Jessica, GÓMEZ PÉREZ, Ana maría, VÁZQUEZ RUIZ, Zenaida, SHYAM, Sangheeta, ORTEGA AZORÍN, Carolina, TALENS, Natàlia, PEÑA ORIHUELA, Patricia j., ONCINA CÁNOVAS, Alejandro, DIEZ ESPINO, Javier, BABIO, Nancy, FITÓ COLOMER, Montserrat, LAMUELA RAVENTÓS, Rosa ma.. Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health<br />. _Molecular Nutrition & Food Research_. 2023. Vol. e2300183. [consulta: 20 de gener de 2026]. ISSN: 1613-4125. [Disponible a: https://hdl.handle.net/2445/208252]