Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health<br />

Abstract

<p>Scope: Diets rich in polyphenols has been associated with better cognitive performance. The aim of this study is to</p><p>assess the relationship between microbial phenolic metabolites (MPM) in urine and cognition in the context of an older</p><p>population at high cardiovascular risk.</p><p>Methods and results: A cross-sectional analysis is conducted in 400 individuals of the PREDIMED-Plus study. Liquid</p><p>chromatography coupled to mass spectrometry is used to identify urinaryMPM.Mediterranean diet (MedDiet) adherence</p><p>is estimated with a 17-item questionnaire and cognitive function is evaluated with a battery of neuropsychological tests.</p><p>Multivariable-adjusted linear regression models are fitted to assess the relationship of urinary MPM with the MedDiet</p><p>and cognitive tests. Protocatechuic acid and enterolactone glucuronide are associated with higher adherence to the</p><p>MedDiet. Regarding cognitive function, protocatechuic acid, vanillic acid glucuronide, 3-hydroxybenzoic acid, enterodiol</p><p>glucuronide, and enterolactone glucuronide are directly associated with a global composite score of all the cognitive tests.</p><p>Furthermore, protocatechuic acid and enterolactone glucuronide are associated with higher scores in the Mini-Mental</p><p>State Examination, whereas enterodiol glucuronide is associated with improved Clock Drawing Test scores.</p><p>Conclusions: These results suggest that the MedDiet is linked to MPM associated with better cognitive performance in</p><p>an older population.</p>