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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/191028
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
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Background: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
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MARTÍN-PELÁEZ, Sandra, SERRA MAJEM, Lluís, CANO IBÁÑEZ, Naomi, MARTÍNEZ-GONZÁLEZ, Miguel ángel, SALAS SALVADÓ, Jordi, CORELLA PIQUER, Dolores, LASSALE, Camille, MARTÍNEZ, J. alfredo, ALONSO GÓMEZ, Ángel m., WÄRNBERG, Julia, VIOQUE, Jesús, ROMAGUERA, Dora, LÓPEZ MIRANDA, José, ESTRUCH RIBA, Ramon, TINAHONES, Francisco j., LAPETRA, José, FERNÁNDEZ ARANDA, Fernando, BUENO CAVANILLAS, Aurora, TUR, Josep a., MARTÍN SÁNCHEZ, Vicente, PINTÓ SALA, Xavier, DELGADO RODRIGUEZ, Miguel, MATÍA MARTÍN, Pilar, VIDAL I CORTADA, Josep, VÁZQUEZ, Clotilde, DAIMIEL, Lidia, ROS RAHOLA, Emilio, TOLEDO ATUCHA, Estefanía, NISHI, Stephanie k., SORLÍ, José v., MALCAMPO, Mireia, ZULET, M. angeles, MORENO RODRÍGUEZ, Anai, CUETO GALÁN, Raquel, VIVANCOS APARICIO, Diego, COLOM, Antoni, GARCÍA RÍOS, Antonio, CASAS RODRÍGUEZ, Rosa m., BERNAL LÓPEZ, M. rosa, SANTOS LOZANO, Jose manuel, VÁZQUEZ RUIZ, Zenaida, GÓMEZ MARTÍNEZ, Carlos, ORTEGA AZORÍN, Carolina, DEL VAL, Jose luís, ABETE, Itziar, GOIKOETXEA BAHON, Amaia, PASCUAL, Elena, BECERRA TOMÁS, Nerea, CHILLARÓN, Juan j., SÁNCHEZ-VILLEGAS, Almudena. Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. _PLoS One_. 2022. Vol. 17, núm. 4, pàgs. e0265079. [consulta: 24 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/191028]