An aged bone marrow niche restrains rejuvenated hematopoietic stem cells

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dc.contributor.authorGuidi, Novella
dc.contributor.authorMarka, Gina
dc.contributor.authorSakk, Vadim
dc.contributor.authorZheng, Yi
dc.contributor.authorFlorian, Maria Carolina
dc.contributor.authorGeiger, Hartmut
dc.date.accessioned2022-03-28T13:25:52Z
dc.date.available2022-03-28T13:25:52Z
dc.date.issued2021-04-13
dc.date.updated2022-03-25T10:12:23Z
dc.description.abstractAging-associated leukemia and aging-associated immune remodeling are in part caused by aging of hematopoietic stem cells (HSCs). An increase in the activity of the small RhoGTPase cell division control protein 42 (Cdc42) within HSCs causes aging of HSCs. Old HSCs, treated ex vivo with a specific inhibitor of Cdc42 activity termed CASIN, stay rejuvenated upon transplantation into young recipients. We determined in this study the influence of an aged niche on the function of ex vivo rejuvenated old HSCs, as the relative contribution of HSCs intrinsic mechanisms vs extrinsic mechanisms (niche) for aging of HSCs still remain unknown. Our results show that an aged niche restrains the function of ex vivo rejuvenated HSCs, which is at least in part linked to a low level of the cytokine osteopontin found in aged niches. The data imply that sustainable rejuvenation of the function of aged HSCs in vivo will need to address the influence of an aged niche on rejuvenated HSCs.
dc.format.extent6 p.
dc.format.mimetypeapplication/pdf
dc.identifier.issn1549-4918
dc.identifier.pmid33847429
dc.identifier.urihttps://hdl.handle.net/2445/184459
dc.language.isoeng
dc.publisherWiley
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1002/stem.3372
dc.relation.ispartofSTEM CELLS, 2021, vol 39, num 8, p. 1101-1106
dc.relation.urihttps://doi.org/10.1002/stem.3372
dc.rightscc by-nc-nd (c) Guidi, Novella et al, 2022
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationMedul·la òssia
dc.subject.classificationRejoveniment
dc.subject.otherBone marrow
dc.subject.otherRejuvenation
dc.titleAn aged bone marrow niche restrains rejuvenated hematopoietic stem cells
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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