El CRAI romandrà tancat del 24 de desembre de 2025 al 6 de gener de 2026. La validació de documents es reprendrà a partir del 7 de gener de 2026.
El CRAI permanecerá cerrado del 24 de diciembre de 2025 al 6 de enero de 2026. La validación de documentos se reanudará a partir del 7 de enero de 2026.
From 2025-12-24 to 2026-01-06, the CRAI remain closed and the documents will be validated from 2026-01-07.
 
Miniatura

Fitxers

1471-2377-10-77.pdf (1.16 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2010

Llicència de publicació

cc-by (C) Fernandez-Espejo et al., 2010
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/13754

Combination of diffusion tensor and functional magnetic resonance imaging during recovery from the vegetative state

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1186/1471-2377-10-77

Resum

Background: The rate of recovery from the vegetative state (VS) is low. Currently, little is known of the mechanisms and cerebral changes that accompany those relatively rare cases of good recovery. Here, we combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to study the evolution of one VS patient at one month post-ictus and again twelve months later when he had recovered consciousness. Methods fMRI was used to investigate cortical responses to passive language stimulation as well as task-induced deactivations related to the default-mode network. DTI was used to assess the integrity of the global white matter and the arcuate fasciculus. We also performed a neuropsychological assessment at the time of the second MRI examination in order to characterize the profile of cognitive deficits. Results: fMRI analysis revealed anatomically appropriate activation to speech in both the first and the second scans but a reduced pattern of task-induced deactivations in the first scan. In the second scan, following the recovery of consciousness, this pattern became more similar to that classically described for the default-mode network. DTI analysis revealed relative preservation of the arcuate fasciculus and of the global normal-appearing white matter at both time points. The neuropsychological assessment revealed recovery of receptive linguistic functioning by 12-months post-ictus. Conclusions: These results suggest that the combination of different structural and functional imaging modalities may provide a powerful means for assessing the mechanisms involved in the recovery from the VS.

Matèries

Neurologia, Mort cerebral

Matèries (anglès)

Neurology, Brain death

Citació

Col·leccions

Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Medicina)

Citació

FERNÁNDEZ-ESPEJO, Davinia, JUNQUÉ I PLAJA, Carme, CRUSE, Damian, BERNABEU GUITART, Montserrat, ROIG-ROVIRA, Teresa, FÀBREGAS JULIÀ, Neus, RIVAS, Eva, MERCADER, José m.. Combination of diffusion tensor and functional magnetic resonance imaging during recovery from the vegetative state. _BMC Neurology 2010_. 10:77. [consulta: 8 de gener de 2026]. ISSN: 1471-2377. [Disponible a: https://hdl.handle.net/2445/13754]

Exportar metadades

JSON - METS

Compartir registre