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Accepted version

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2016-01-21

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/114162

High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

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https://doi.org/10.1039/C5CC07619F

Abstract

We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.

Subject

Síntesi de pèptids, Física de l'estat sòlid, ADN, Càncer

Subject (English)

Peptide synthesis, Solid state physics, DNA, Cancer

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Articles publicats en revistes (Química Inorgànica i Orgànica)

Citation

GAMBA, Ilaria, et al. High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides. Chemical Communications. 2016. Vol. 52, num. 6, pags. 1234-1237. ISSN 1359-7345. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/114162

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