High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides

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dc.contributor.authorGamba, Ilaria
dc.contributor.authorSalvadó, Iria
dc.contributor.authorBrissos, Rosa F.
dc.contributor.authorGámez Enamorado, Patrick
dc.contributor.authorBrea, José
dc.contributor.authorLoza, María Isabel
dc.contributor.authorVázquez, M. Eugenio
dc.contributor.authorVázquez López, Miguel
dc.date.accessioned2017-07-21T07:23:43Z
dc.date.available2017-07-21T07:23:43Z
dc.date.issued2016-01-21
dc.date.updated2017-07-21T07:23:43Z
dc.description.abstractWe demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec656122
dc.identifier.issn1359-7345
dc.identifier.pmid26611126
dc.identifier.urihttps://hdl.handle.net/2445/114162
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1039/C5CC07619F
dc.relation.ispartofChemical Communications, 2016, vol. 52, num. 6, p. 1234-1237
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055/EU//METBIOCAT
dc.relation.urihttps://doi.org/10.1039/C5CC07619F
dc.rights(c) Gamba, Ilaria et al., 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)
dc.subject.classificationSíntesi de pèptids
dc.subject.classificationFísica de l'estat sòlid
dc.subject.classificationADN
dc.subject.classificationCàncer
dc.subject.otherPeptide synthesis
dc.subject.otherSolid state physics
dc.subject.otherDNA
dc.subject.otherCancer
dc.titleHigh-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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