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L01_2016_Cell Chemical Biology_23_929_OA.pdf (277.55 KB)

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Article

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Accepted version

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2016-08-18

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cc by-nc-nd (c) Elsevier, 2016
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/156117

OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity

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https://doi.org/10.1016/j.chembiol.2016.06.013

Abstract

OptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system.

Subject

Sistema nerviós, Dolor crònic

Subject (English)

Nervous system, Chronic pain

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Publicacions de projectes de recerca finançats per la UE

Citation

ROVIRA, Xavier, et al. OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity. Cell Chemical Biology. 2016. Vol. 23, num. 8 p. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/156117

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