OptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activity

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dc.contributor.authorRovira, Xavier
dc.contributor.authorTrapero, Ana
dc.contributor.authorPittolo, Silvia
dc.contributor.authorZussy, Charleine
dc.contributor.authorFaucherre, Adèle
dc.contributor.authorJopling, Chris
dc.contributor.authorGiraldo, Jesús
dc.contributor.authorPin, Jean-Philippe
dc.contributor.authorGorostiza Langa, Pablo Ignacio
dc.contributor.authorGoudet, Cyril
dc.contributor.authorLlebaria Soldevila, Amadeu
dc.date.accessioned2020-04-20T16:06:02Z
dc.date.available2020-04-20T16:06:02Z
dc.date.issued2016-08-18
dc.description.abstractOptoGluNAM4.1, a negative allosteric modulator (NAM) of metabotropic glutamate receptor 4 (mGlu4) contains a reactive group that covalently binds to the receptor and a blue-light-activated, fast-relaxing azobenzene group that allows reversible receptor activity photocontrol in vitro and in vivo. OptoGluNAM4.1 induces light-dependent behavior in zebrafish and reverses the activity of the mGlu4 agonist LSP4-2022 in a mice model of chronic pain, defining a photopharmacological tool to better elucidate the physiological roles of the mGlu4 receptor in the nervous system.ca
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2445/156117
dc.language.isoengca
dc.publisherElsevier
dc.relation.ispartofCell Chemical Biology, 2016, vol. 23, num. 8 p. 929-934
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/785907/EU//HBP_SGA2ca
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/270483/EU//FOCUS
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/335011/EU//THERALIGHT
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/210355/EU//OPTICALBULLET
dc.relation.urihttps://doi.org/10.1016/j.chembiol.2016.06.013
dc.rightscc by-nc-nd (c) Elsevier, 2016
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
dc.subject.classificationSistema nerviós
dc.subject.classificationDolor crònic
dc.subject.otherNervous system
dc.subject.otherChronic pain
dc.titleOptoGluNAM4.1, a Photoswitchable allosteric antagonist for real-time control of mGlu4 receptor activityca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion

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