Magnetic nanoparticles: From diagnosis to therapy

Abstract

Magnetic nanoparticles have proven to be promising theranostic agents, namely tools for therapy and diagnosis. Among them, superparamagnetic iron oxide nanoparticles (SPIONs) highlight for their biocompatibility and reduced toxicity. Here, we describe the synthesis and characterization of SPIONs by co-precipitation of ferric and ferrous salts under mild conditions. These particles were able to accumulate in inflamed areas fact that was increased upon the application of an external magnetic field. Resonance magnetic imaging studies have shown their suitability as negative contrast agents for diagnosis. In addition, hybrid nanoparticles were obtained by incorporating the above described SPIONs into liposomes or nanoemulsions. The findings have confirmed the high potential of these systems for biomedical applications.