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Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis
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Background: atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. Objective: to analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. Methods: a systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. Results: ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). Conclusions: periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatment.
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Podeu consultar la versió en castellà del document a: http://hdl.handle.net/2445/153580
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ROCA MILLAN, Elisabet, GONZÁLEZ NAVARRO, Beatriz, SABATER RECOLONS, Ma. del mar, MARÍ ROIG, Antonio, JANÉ SALAS, Enric, LÓPEZ LÓPEZ, José. Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis. _Medicina Oral_. Patología Oral y Cirugía Bucal. Vol. 2018, núm. 23, pàgs. 6. [consulta: 23 de gener de 2026]. ISSN: 1698-4447. [Disponible a: https://hdl.handle.net/2445/145578]