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Published version

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2023-05-02

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/220233

Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder

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https://doi.org/10.1212/WNL.0000000000207147

Abstract

Real-time quaking-induced conversion (RT-QuIC) assay detects misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies Parkinson disease and dementia with Lewy bodies. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of these synucleinopathies. We aimed to compare the ability of RT-QuIC to identify AS in the skin and CSF of patients with IRBD.

Subject

Trastorns del son, Demència amb cossos de Lewy, Malaltia de Parkinson

Subject (English)

Sleep disorders, Lewy body dementia, Parkinson's disease

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

IRANZO, Alex, et al. Misfolded α-Synuclein Assessment in the Skin and CSF by RT-QuIC in Isolated REM Sleep Behavior Disorder. Neurology. 2023. Vol. 100, num. 18, pags. E1944-E1954. ISSN 0028-3878. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/220233

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