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Langerhans Repositori.pdf (5.52 MB)

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2025-01-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/227768

Fatal Langerhans Cell Histiocytosis in an 84-Year-Old Man: A Case Report

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https://doi.org/10.1097/DAD.0000000000003001

Abstract

Langerhans cell histiocytosis (LCH) is a rare myeloid neoplastic disorder with highly variable clinical presentations. In this article, we describe an unusual case of an 84-year-old man with initial focal truncal LCH who later developed multisystem involvement, including severe hepatic infiltration leading to fulminant hepatic failure. This case highlights the diagnostic challenge of differentiating LCH hepatic involvement from methotrexate toxicity and the poor prognosis associated with hepatic LCH. Early recognition and a multidisciplinary approach are crucial for improving outcomes in patients with multisystem LCH.

Subject

Mort cel·lular, Malalties de les persones grans, Malalties de l'aparell genitourinari

Subject (English)

Cell death, Older people diseases, Genitourinary organs diseases

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Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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MANSILLA POLO, Miguel, et al. Fatal Langerhans Cell Histiocytosis in an 84-Year-Old Man: A Case Report. American Journal of Dermatopathology. 2025. Vol. 47, num. 8, pags. 648-650. ISSN 2307-8960. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/227768

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