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2020

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cc by-nc (c) Leurs et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/173069

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

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https://doi.org/10.1177/1352458519845844

Resum

Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mix- ture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI=4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS.

Matèries

Esclerosi múltiple, Marcadors bioquímics

Matèries (anglès)

Multiple sclerosis, Biochemical markers

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

LEURS, C. e., TWAALFHOVEN, H., LISSENBERG-WITTE, B. i., VAN PESCH, V., DUJMOVIC, Irena, DRULOVIC, J., CASTELLAZZI, M., BELLINI, T., PUGLIATTI, M., KUHLE, J., VILLAR, Luisa m., ÁLVAREZ CERMEÑO, José c., ALVAREZ LAFUENTE, R., HEGEN, H., DEISENHAMMER, F., WALCHHOFER, L. m., THOUVENOT, E., COMABELLA, Manuel, MONTALBÁN GAIRÍN, Xavier, SAIZ HINAREJOS, Albert, PUMA, D. la, VERCAMMEN, M., VANOPDENBOSCH, L., UITDEHAAG, B. m. j., KILLESTEIN, J., BRIDEL, C., TEUNISSEN, C.. Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study. _Multiple Sclerosis Journal_. 2020. Vol. 26, núm. 8, pàgs. 912-923. [consulta: 24 de gener de 2026]. ISSN: 1352-4585. [Disponible a: https://hdl.handle.net/2445/173069]

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