FGF21 mediates the lipid metabolism response to amino acid starvation

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dc.contributor.authorSousa Coelho, Ana Luisa de
dc.contributor.authorRelat Pardo, Joana
dc.contributor.authorHondares, E.
dc.contributor.authorPérez Martí, Albert
dc.contributor.authorRibas Aulinas, Francesc
dc.contributor.authorVillarroya i Gombau, Francesc
dc.contributor.authorMarrero González, Pedro F.
dc.contributor.authorHaro Bautista, Diego
dc.date.accessioned2020-05-25T09:50:57Z
dc.date.available2020-05-25T09:50:57Z
dc.date.issued2013-05-09
dc.date.updated2020-05-25T09:50:57Z
dc.description.abstractAbstract Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fi broblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21- defi cient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation. ¿De Sousa-Coelho, A. L., J. Relat, E. Hondares, A. Pérez-Martí, F. Ribas, F. Villarroya, P. F. Marrero, and D. Haro. FGF21 mediates the lipid metabolism response to amino acid starvation.
dc.format.extent12 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec627115
dc.identifier.issn0022-2275
dc.identifier.pmid23661803
dc.identifier.urihttps://hdl.handle.net/2445/162215
dc.language.isoeng
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1194/jlr.M033415
dc.relation.ispartofJournal of Lipid Research, 2013, vol. 54, num. 7, p. 1786-1797
dc.relation.urihttps://doi.org/10.1194/jlr.M033415
dc.rights(c) American Society for Biochemistry and Molecular Biology, 2013
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
dc.subject.classificationMetabolisme dels lípids
dc.subject.classificationTeixit adipós
dc.subject.classificationFactors de creixement
dc.subject.classificationAminoàcids
dc.subject.classificationRatolins
dc.subject.otherLipid metabolism
dc.subject.otherAdipose tissues
dc.subject.otherGrowth factors
dc.subject.otherAmino acids
dc.subject.otherMice
dc.titleFGF21 mediates the lipid metabolism response to amino acid starvation
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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