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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/179354
Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
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Keratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.
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SUBIRÓS FUNOSAS, Ramon, et al. Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas. Chemical Science. 2020. Vol. 11, num. 1368-1374. ISSN 2041-6520. [consulted: 14 of June of 2026]. Available at: https://hdl.handle.net/2445/179354