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Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

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dc.contributor.authorSubirós Funosas, Ramon
dc.contributor.authorCheuk Lam Ho, Vivian
dc.contributor.authorBarth, Nicole D.
dc.contributor.authorMendive Tapia, Lorena
dc.contributor.authorPappalardo, Morena
dc.contributor.authorBarril Alonso, Xavier
dc.contributor.authorMa, Ruoyu
dc.contributor.authorZhang, Cheng-Bin
dc.contributor.authorQian, Bin-Zhi
dc.contributor.authorSintes Marcos, Miquel
dc.contributor.authorGhashghaei, Ouldouz
dc.contributor.authorLavilla Grífols, Rodolfo
dc.contributor.authorVendrell, Marc
dc.date.accessioned2021-07-22T11:47:36Z
dc.date.available2021-07-22T11:47:36Z
dc.date.issued2020-01-20
dc.date.updated2021-07-22T11:47:36Z
dc.description.abstractKeratin 1 (KRT1) is overexpressed in squamous carcinomas and associated with aggressive pathologies in breast cancer. Herein we report the design and preparation of the first Trp-based red fluorogenic amino acid, which is synthetically accessible in a few steps and displays excellent photophysical properties, and its application in a minimally-disruptive labelling strategy to prepare a new fluorogenic cyclopeptide for imaging of KRT1+ cells in whole intact tumour tissues.
dc.format.extent7 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec695128
dc.identifier.issn2041-6520
dc.identifier.pmid34123261
dc.identifier.urihttps://hdl.handle.net/2445/179354
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1039/C9SC05558D
dc.relation.ispartofChemical Science, 2020, vol. 11, p. 1368-1374
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/771443/EU//DYNAFLUORS
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/716379/EU//MetResistance
dc.relation.urihttps://doi.org/10.1039/C9SC05558D
dc.rightscc-by (c) Subirós Funosas, Ramon et al., 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationPèptids
dc.subject.classificationAminoàcids
dc.subject.classificationApoptosi
dc.subject.otherPeptides
dc.subject.otherAmino acids
dc.subject.otherApoptosis
dc.titleFluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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