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2023-09-22

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cc-by (c) Mela, V. et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/209237

The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery

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Recurs relacionat

https://doi.org/10.3390/nu15194109

Resum

Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.

Matèries

Obesitat, Cirurgia de l'obesitat, Depressió psíquica

Matèries (anglès)

Obesity, Obesity surgery, Mental depression

Citació

Col·leccions

Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MARTÍNEZ-MORENO, Jose M., et al. The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery. Nutrients. 2023. Vol. 15, num. 19. ISSN 2072-6643. [consulted: 11 of August of 2026]. Available at: https://hdl.handle.net/2445/209237

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